Not sure I understand your question correctly but I'll try to answer it anyway.
The guitar solo to Layla by Eric Clapton is played over the chords Dm, Bb and C. These chords are vi IV V (6 4 5) from the F major scale. So you can play F major scale patterns over the whole thing (creating D Aeolian
mode or D natural minor). And because the Dm chord is functioning as the root, you can also just play D minor pentatonic over the whole progression.
I teach about roots, keys and applying guitar scales correctly in
Fretboard Theory Chapter 7.